Xiaflex is a newer, FDA approved, injectable medication that can be used for the treatment of Dupuytren’s contracture. It is a collagenase (collagenase clostridium histolyticum) that specifically attacks and breaks down the collagen fibers associated with Dupuytren’s contracture. It thereby weakens the cord formation(s) and allows them to be manipulated and ruptured. It is an in-office procedure. Local anesthetic is used for the manipulation portion. A hand splint is fashioned and worn for the following 2-4 weeks while sleeping and part time during the day. Recovery time is typically 4 weeks or less. Hand therapy is occasionally needed, but not routinely. In general, Xiaflex is cheaper, quicker, and less painful than surgery. Recurrence rates are similar, as any treatment method utilized for Dupuytren’s contracture addresses the cord formation and not the underlying genetic disorder.